| http://purl.uniprot.org/citations/19816809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19816809 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the alpha-synuclein gene have been linked to rare cases of familial Parkinson's disease (PD). alpha-Synuclein, a 140 amino acid polypeptide, is a major component of Lewy bodies (LB), a pathological hallmark of PD. Transgenic mice, Drosophila and marmosets (Challitrix jacchus) expressing either wild type (WT) or mutant human alpha-synuclein develop motor deficits, LB-like inclusions in some neurons and neuronal degeneration. The effects of human alpha-synuclein were investigated in a neuronal rat cell line (B103). Plasmids expressing WT and mutant human alpha-synuclein regulated by the cytomegalovirus (CMV) promoter were prepared and used for creating stably transfected neuronal rat cell lines. For localizing alpha-synuclein expression, stably transfected neuronal rat cell lines, expressing alpha-synuclein enhanced green fluorescent protein fusion proteins, regulated by either the CMV or the human platelet-derived growth factor ss promoter were generated. Over-expression of WT and A53T alpha-synuclein regulated by CMV promoter in stable transfectants resulted in formation of alpha-synuclein-immunopositive inclusion-like structures and mitochondrial alterations. Taken together, these results suggest that abnormal accumulation of alpha-synuclein could lead to mitochondrial alterations that might result in oxidative stress and eventually, cell death."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12031-009-9289-1"xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Schreiner E."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Ingolic E."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Pfragner R."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Windisch M."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Schwach G."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/author | "Tschemmernegg M."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/name | "J Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/pages | "80-88"xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/title | "Establishment of stably transfected rat neuronal cell lines expressing alpha-synuclein GFP fusion proteins."xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/19816809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19816809 |
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