| http://purl.uniprot.org/citations/19819240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19819240 | http://www.w3.org/2000/01/rdf-schema#comment | "The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubquitin-like MOdifier protein 1 (SUMO-1) in cortical neurons. Delta(9)-THC increased both Mdm2 and SUMO-1 protein expression and induced the deSUMOylation of p53 in a cannabinoid receptor type 1 (CB(1))-receptor dependent manner. We demonstrate that Delta(9)-THC decreased the SUMOylation of the CB(1) receptor. The data reveal a novel role for cannabinoid receptor activation in modulating the SUMO regulatory system."xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.09.056"xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/author | "Campbell V.A."xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/author | "Gowran A."xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/author | "Murphy C.E."xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/pages | "3412-3418"xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/title | "Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain."xsd:string |
| http://purl.uniprot.org/citations/19819240 | http://purl.uniprot.org/core/volume | "583"xsd:string |
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