| http://purl.uniprot.org/citations/19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19820695 | http://www.w3.org/2000/01/rdf-schema#comment | "Helicobacter pylori-initiated chronic gastritis is characterized by the cag pathogenicity island-dependent upregulation of proinflammatory cytokines, which is largely mediated by the transcription factor nuclear factor (NF)-kappaB. However, the cag pathogenicity island-encoded proteins and cellular signalling molecules that are involved in H. pylori-induced NF-kappaB activation and inflammatory response remain unclear. Here, we show that H. pylori virulence factor CagA and host protein transforming growth factor-beta-activated kinase 1 (TAK1) are essential for H. pylori-induced activation of NF-kappaB. CagA physically associates with TAK1 and enhances its activity and TAK1-induced NF-kappaB activation through the tumour necrosis factor receptor-associated factor 6-mediated, Lys 63-linked ubiquitination of TAK1. These findings show that polyubiquitination of TAK1 regulates the activation of NF-kappaB, which in turn is used by H. pylori CagA for the H. pylori-induced inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.210"xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Li J.D."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Blanke S.R."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Chen L.F."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Yang X.D."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Peek R.M."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Lamb A."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Higashi H."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/author | "Tsang Y.H."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/pages | "1242-1249"xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/title | "Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19820695 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19820695 |
| http://purl.uniprot.org/citations/19820695 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19820695 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |
| http://purl.uniprot.org/uniprot/#_B4DRH8-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |
| http://purl.uniprot.org/uniprot/#_B5Z6S0-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |
| http://purl.uniprot.org/uniprot/#_Q62073-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |
| http://purl.uniprot.org/uniprot/#_P25799-mappedCitation-19820695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19820695 |