| http://purl.uniprot.org/citations/19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822078 | http://www.w3.org/2000/01/rdf-schema#comment | "Monocyte chemoattractant protein-1 (MCP-1, CCL-2) binds to the Duffy antigen (DARC) on red blood cells, which act as a sink for several chemokines including MCP-1. In this study it is hypothesized that DARC may alter the pharmacokinetics of infused recombinant human MCP-1 (rhMCP-1). The primary aim of this first in man trial is to compare the pharmacokinetics of rhMCP-1 in Duffy positive and negative individuals. A randomized, double-blinded, placebo-controlled dose escalation trial was conducted on 36 healthy volunteers. Subjects received infusions of 0.02-2.0 microg/kg rhMCP-1 or placebo for one hour. RhMCP-1 displayed linear pharmacokinetics. Duffy negative individuals reached maximal plasma levels significantly earlier, but overall plasma concentration profiles were not altered. rhMCP-1 markedly increased monocyte counts, and estimated EC50 values were 10-fold higher in Duffy positive than in Duffy negative subjects. Increased monocyte counts were associated with decreased surface expression of intercellular adhesion molecule 1 (ICAM-1, CD54). In contrast, neither CCR-2 or CD11b expression, nor markers of platelet or endothelial activation, inflammation and coagulation were altered. RhMCP-1 is a highly selective chemoattractant for monocytes in humans. The Duffy antigen only minimally alters the pharmacokinetics of rhMCP-1 for doses up to 2 microg/kg."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.org/dc/terms/identifier | "doi:10.1177/039463200902200307"xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Jilma B."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Schnee J."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Hilbert J."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Derendorf H."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Spiel A.O."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Leitner J.M."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Firbas C."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/author | "Mayr F.B."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/name | "Int J Immunopathol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/pages | "615-625"xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/title | "Influence of the Duffy antigen on pharmacokinetics and pharmacodynamics of recombinant monocyte chemoattractant protein (MCP-1, CCL-2) in vivo."xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/19822078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19822078 |
| http://purl.uniprot.org/citations/19822078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059T9N9-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059T9V8-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059T9W4-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059TA65-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A1C8Y868-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059TA67-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |
| http://purl.uniprot.org/uniprot/#_A0A059TA82-mappedCitation-19822078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822078 |