| http://purl.uniprot.org/citations/19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822091 | http://www.w3.org/2000/01/rdf-schema#comment | "The receptor for advanced glycation end product (RAGE) is thought to play an important role in inflammation. Chronic fatigue syndrome (CFS) is a long-lasting fatigue that compromises at least 50% of a subject's daily activities without other known cause. Immune dysfunction has been implicated and an association with a peculiar genetic cytokine profile, predisposing to an immunomodulatory response of inflammatory nature, was found. The aim of this study is to analyse RAGE polymorphisms and HLA-DRB1 alleles in seventy-five Italian CFS patients and 141 controls matched for age, sex and ethnicity. These two groups underwent genomic study for RAGE 374T/A and 429C/T promoter polymorphisms; moreover, 46 patients and 186 controls were typed for HLA-DRB1 at low resolution molecular level. Of these, 31 patients and 99 controls also underwent high resolution analysis to define the HLA-DRB1*11 and DRB1*13 alleles. The haplotypes RAGE-374T, DRB1*04; RAGE-374T, DRB1*09; RAGE-374T, DRB1*11; RAGE-374A, DRB1*13; RAGE-429T, DRB1*04 and RAGE-429C, DRB1*11 were significantly more frequent in CFS patients, whereas RAGE-429C, DRB1*07 would seem protective. A significantly lower frequency of DRB1*1104 (5.4% vs 12.9% p=0.04, OR=0.39) and a significantly higher frequency of HLA-DRB1*1301 (13.0% vs 5.1% p=0.006, OR= 2.79) were found in CFS patients. A synergic effect was observed with RAGE polymorphism. The OR values strengthened in the following cis combinations: RAGE-374A, HLA-DRB1*1104 (OR=0.27) and RAGE-374A, HLADRB1*1301 (OR=6.23). HLA haplotypes rather than single alleles of RAGE or of DRB1 genes seem to be involved in CFS, probably including a subregion of major interest."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.org/dc/terms/identifier | "doi:10.1177/039463200902200320"xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Sbarsi I."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Martinetti M."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Pizzochero C."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Cuccia M."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "De Silvestri A."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Lorusso L."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Carlo-Stella N."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/author | "Bozzini S."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/name | "Int J Immunopathol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/pages | "745-754"xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/title | "Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome."xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/19822091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19822091 |
| http://purl.uniprot.org/citations/19822091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-19822091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822091 |