| http://purl.uniprot.org/citations/19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822657 | http://www.w3.org/2000/01/rdf-schema#comment | "J proteins are structurally diverse, obligatory cochaperones of Hsp70s, each with a highly conserved J domain that plays a critical role in the stimulation of Hsp70's ATPase activity. The essential protein, Cwc23, is one of 13 J proteins found in the cytosol and/or nucleus of Saccharomyces cerevisiae. We report that a partial loss-of-function CWC23 mutant has severe, global defects in pre-mRNA splicing. This mutation leads to accumulation of the excised, lariat form of the intron, as well as unspliced pre-mRNA, suggesting a role for Cwc23 in spliceosome disassembly. Such a role is further supported by the observation that this mutation results in reduced interaction between Cwc23 and Ntr1 (SPP382), a known component of the disassembly pathway. However, Cwc23 is a very atypical J protein. Its J domain, although functional, is dispensable for both cell viability and pre-mRNA splicing. Nevertheless, strong genetic interactions were uncovered between point mutations encoding alterations in Cwc23's J domain and either Ntr1 or Prp43, a DExD/H-box helicase essential for spliceosome disassembly. These genetic interactions suggest that Hsp70-based chaperone machinery does play a role in the disassembly process. Cwc23 provides a unique example of a J protein; its partnership with Hsp70 plays an auxiliary, rather than a central, role in its essential cellular function."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00842-09"xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/author | "Inada M."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/author | "Lee T."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/author | "Craig E.A."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/author | "Sahi C."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/author | "Pleiss J.A."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/title | "Cwc23, an essential J protein critical for pre-mRNA splicing with a dispensable J domain."xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19822657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19822657 |
| http://purl.uniprot.org/citations/19822657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19822657 |
| http://purl.uniprot.org/uniprot/P52868#attribution-D4DD68075B1C1F988C42E1297EBAE29B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P52868-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P53863-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P53940-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_A0A8H4FBK3-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P39101-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P39102-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P25294-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_Q06411-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |
| http://purl.uniprot.org/uniprot/#_P25491-mappedCitation-19822657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19822657 |