| http://purl.uniprot.org/citations/19822757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822757 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitination by the anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The human APC/C promotes the degradation of mitotic regulators by assembling K11-linked ubiquitin chains, the formation of which is initiated by its E2 UbcH10. Here, we identify the conserved Ube2S as a K11-specific chain elongating E2 for human and Drosophila APC/C. Ube2S depends on the cell cycle-dependent association with the APC/C activators Cdc20 and Cdh1 for its activity. While depletion of Ube2S already inhibits APC/C in cells, the loss of the complete UbcH10/Ube2S-module leads to dramatic stabilization of APC/C substrates, severe spindle defects, and a strong mitotic delay. Ube2S and UbcH10 are tightly co-regulated in the cell cycle by APC/C-dependent degradation. We conclude that UbcH10 and Ube2S constitute a physiological E2-module for APC/C, the activity of which is required for spindle assembly and cell division."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0907887106"xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0907887106"xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Karpen G.H."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Karpen G.H."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Williamson A."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Williamson A."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Rape M."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Rape M."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Wickliffe K.E."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Wickliffe K.E."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Mellone B.G."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/author | "Mellone B.G."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/pages | "18213-18218"xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/pages | "18213-18218"xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/title | "Identification of a physiological E2 module for the human anaphase-promoting complex."xsd:string |
| http://purl.uniprot.org/citations/19822757 | http://purl.uniprot.org/core/title | "Identification of a physiological E2 module for the human anaphase-promoting complex."xsd:string |