| http://purl.uniprot.org/citations/19822898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19822898 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor receptor 1 (VEGFR1) is a marker for endothelial-specific gene expression. We previously reported that the human VEGFR1 promoter (between -748 and +284) contains information for expression in the intact endothelium of transgenic mice. The objective of this study was to dissect the cis-regulatory elements underlying VEGFR1 promoter activity in vitro and in vivo. In primary endothelial cells, binding sites for E74-like factor 1 (ELF-1; between -49 and -52), cyclic adenosine monophosphate response element binding (CREB; between -74 and -81), and early growth response factor 1/3 (EGR-1/3; between -16 to -25) were shown to play a positive role in gene transcription, whereas a putative E26 transformation-specificsequence (ETS) motif between -36 and -39 had a net negative effect on promoter activity. When targeted to the Hprt locus of mice, mutations of the ELF-1 binding site and the CRE element reduced promoter activity in the embryonic vasculature and resulted in a virtual loss of expression in adult endothelium. Postnatally, the EGR binding site mutant displayed significantly reduced promoter activity in a subset of vascular beds. In contrast, mutation of the -39 ETS site resulted in increased LacZ staining in multiple vascular beds. Together, these results provide new insights into the transcriptional regulatory mechanisms of VEGFR1."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-05-220434"xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Yano K."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Oettgen P."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Minami T."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Shih S.C."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Jin E."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Aird W.C."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Spokes K.C."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Suehiro J."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Janes L."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Beeler D."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Nikolova-Krstevski V."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/author | "Regan E."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/pages | "5557-5566"xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/title | "Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo."xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19822898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19822898 |