| http://purl.uniprot.org/citations/19828440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19828440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19828440 | http://www.w3.org/2000/01/rdf-schema#comment | "Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 larvae can enter the developmentally quiescent, stress-resistant dauer larva stage, enabling them to survive for prolonged periods before completing development. A specific progression of cell division and differentiation events occurs with fidelity during the larval stages, regardless of whether an animal undergoes continuous or dauer-interrupted development. The temporal patterning of developmental events is controlled by the heterochronic genes, whose products include microRNAs (miRNAs) and regulatory proteins. One of these proteins, the DAF-12 nuclear hormone receptor, modulates the transcription of certain let-7-family miRNAs, and also mediates the choice between the continuous vs. dauer-interrupted life history. Here, we report a complex feedback loop between DAF-12 and the let-7-family miRNAs involving both the repression of DAF-12 by let-7-family miRNAs and the ligand-modulated transcriptional activation and repression of the let-7-Fam miRNAs by DAF-12. We propose that this feedback loop functions to ensure robustness of cell fate decisions and to coordinate cell fate with developmental arrest."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908131106"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908131106"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Ambros V."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Ambros V."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Hammell C.M."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Hammell C.M."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Karp X."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/author | "Karp X."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/pages | "18668-18673"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/pages | "18668-18673"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/title | "A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/title | "A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19828440 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19828440 |
| http://purl.uniprot.org/citations/19828440 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19828440 |
| http://purl.uniprot.org/citations/19828440 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19828440 |
| http://purl.uniprot.org/citations/19828440 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19828440 |