| http://purl.uniprot.org/citations/19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19828754 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant promoter methylation of retinoic acid receptor-beta(2) (RAR-beta(2)) is frequently detected in hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC); however, the mechanism of methylation and its biological significance are unknown. This study showed that HBx, the principal oncogene product of HBV, induced promoter hypermethylation of RAR-beta(2) via upregulation of DNA methyltransferases 1 and 3a, resulting in downregulation of its expression in human HCC cells. In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA. As a consequence, HBx-expressing cells were less susceptible to RA-induced cell growth inhibition compared with control cells. These effects almost completely disappeared when levels of RAR-beta(2) in HBx-expressing cells were restored by treatment with a universal DNA methylation inhibitor, 5-aza-2'-deoxycytidine. As RAR-beta(2) is a major executor of the anti-tumour potential of RA, its epigenetic downregulation by HBx is likely to be an important step during HBV-mediated tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.015149-0"xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/author | "Jung J.K."xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/author | "Jang K.L."xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/name | "J Gen Virol"xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/pages | "493-500"xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/title | "Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation."xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/19828754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19828754 |
| http://purl.uniprot.org/citations/19828754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19828754 |
| http://purl.uniprot.org/uniprot/#_A8K7L7-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_B6ZGR8-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_A0A8I5KWP3-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_B4DSI3-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_F1D8S6-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q15299-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q5QHG3-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_P10826-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q86UC5-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q6FHY0-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q3SB16-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |
| http://purl.uniprot.org/uniprot/#_Q6NSX7-mappedCitation-19828754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19828754 |