| http://purl.uniprot.org/citations/19830702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19830702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19830702 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence has shown that GSK3beta plays a pivotal role in regulating the specification of axons and dendrites. Our previous study has shown a novel GSK3beta interaction protein (GSKIP) able to negatively regulate GSK3beta in Wnt signaling pathway. To further characterize how GSKIP functions in neurons, human neuroblastoma SH-SY5Y cells treated with retinoic acid (RA) to differentiate to neuron-like cells was used as a model. Overexpression of GSKIP prevents neurite outgrowth in SH-SY5Y cells. GSKIP may affect GSK3beta activity on neurite outgrowth by inhibiting the specific phosphorylation of tau (ser396). GSKIP also increases beta-catenin in the nucleus and raises the level of cyclin D1 to promote cell-cycle progression in SH-SY5Y cells. Additionally, overexpression of GSKIP downregulates N-cadherin expression, resulting in decreased recruitment of beta-catenin. Moreover, depletion of beta-catenin by small interfering RNA, neurite outgrowth is blocked in SH-SY5Y cells. Altogether, we propose a model to show that GSKIP regulates the functional interplay of the GSK3beta/beta-catenin, beta-catenin/cyclin D1, and beta-catenin/N-cadherin pool during RA signaling in SH-SY5Y cells."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22362"xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22362"xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hsu C.Y."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hsu C.Y."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Lin C.C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Lin C.C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Chou C.H."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Chou C.H."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hong Y.R."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hong Y.R."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Howng S.L."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Howng S.L."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hsu C.M."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hsu C.M."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hwang C.C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/author | "Hwang C.C."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/19830702 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |