| http://purl.uniprot.org/citations/19836339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19836339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19836339 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the interleukin-1 (IL-1) family of cytokines play major roles in host defense and immune system regulation in infectious and inflammatory diseases. IL-1 cytokines trigger a biological response in effector cells by assembling a heterotrimeric signaling complex with two IL-1 receptor chains, a high-affinity primary receptor and a low-affinity coreceptor. To gain insights into the signaling mechanism of the novel IL-1-like cytokine IL-33, we first solved its solution structure and then performed a detailed biochemical and structural characterization of the interaction between IL-33, its primary receptor ST2, and the coreceptor IL-1RAcP. Using nuclear magnetic resonance data, we obtained a model of the IL-33/ST2 complex in solution that is validated by small-angle X-ray scattering (SAXS) data and is similar to the IL-1beta/IL-1R1 complex. We extended our SAXS analysis to the IL-33/ST2/IL-1RAcP and IL-1beta/IL-1R1/IL-1RAcP complexes and propose a general model of the molecular architecture of IL-1 ternary signaling complexes."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2009.08.009"xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2009.08.009"xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Lingel A."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Lingel A."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Pan B."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Pan B."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Appleton B.A."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Appleton B.A."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Fairbrother W.J."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Fairbrother W.J."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Wiesmann C."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Wiesmann C."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Weiss T.M."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Weiss T.M."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Niebuhr M."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/author | "Niebuhr M."xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19836339 | http://purl.uniprot.org/core/name | "Structure"xsd:string |