| http://purl.uniprot.org/citations/19838199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19838199 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) are increasingly recognized as key participants in various autoimmune diseases, including multiple sclerosis. Although sets of transcription factors and cytokines are known to regulate T(H)-17 differentiation, the role of noncoding RNA is poorly understood. Here we identify a T(H)-17 cell-associated microRNA, miR-326, whose expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). In vivo silencing of miR-326 resulted in fewer T(H)-17 cells and mild EAE, and its overexpression led to more T(H)-17 cells and severe EAE. We also found that miR-326 promoted T(H)-17 differentiation by targeting Ets-1, a negative regulator of T(H)-17 differentiation. Our data show a critical role for microRNA in T(H)-17 differentiation and the pathogenesis of multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1798"xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Zhao G."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Ye Z."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Pei G."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/author | "Du C."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/pages | "1252-1259"xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/title | "MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19838199 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19838199 |
| http://purl.uniprot.org/citations/19838199 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19838199 |
| http://purl.uniprot.org/uniprot/P06332#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |
| http://purl.uniprot.org/uniprot/P22646#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |
| http://purl.uniprot.org/uniprot/P01731#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |
| http://purl.uniprot.org/uniprot/P01580#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |
| http://purl.uniprot.org/uniprot/Q62386#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |
| http://purl.uniprot.org/uniprot/P06800#attribution-EEACCA2E3B38418D4A661B1B739C33F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19838199 |