| http://purl.uniprot.org/citations/19839723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19839723 | http://www.w3.org/2000/01/rdf-schema#comment | "Many investigations showed that cobalt exposure could induce apoptosis both in cells and tissues. However, appropriate in vivo animal models to assess the underlying mechanisms of cobalt-induced apoptosis are currently unavailable. The model organism, Caenorhabditis elegans, has been shown to be a good model for evaluating many biological processes. This study detected significant cobalt induced germline cell apoptosis after 12-h exposure; thus demonstrating that C. elegans could be a mammalian in vivo substitute model to study mechanisms of apoptosis. Then knockout gene C. elegans strains were utilized to investigate the relationship between cobalt-induced apoptosis and relevant signal pathways, which were involved in DNA damage and repair, apoptosis regulation, and damage signal transduction. The results presented here demonstrated that cobalt-induced apoptosis was independent of the DNA damage response gene, such as hus-1, p53/cep-1, and egl-1. The loss-of-function of the genes that related to JNK and p38 MAPK signaling cascades suppressed cobalt-induced germline apoptosis, while ERK signaling cascades have no effect on the cobalt-induced germline apoptosis."xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.org/dc/terms/identifier | "doi:10.3109/15376510903350363"xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/author | "Chong R."xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/author | "Ke-zhou C."xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/author | "Zeng-liang Y."xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/name | "Toxicol Mech Methods"xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/pages | "541-546"xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/title | "Induction of germline apoptosis by cobalt and relevant signal transduction pathways in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19839723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19839723 |
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| http://purl.uniprot.org/uniprot/#_B3WFU5-mappedCitation-19839723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19839723 |
| http://purl.uniprot.org/uniprot/#_G5EDF7-mappedCitation-19839723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19839723 |
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| http://purl.uniprot.org/uniprot/#_Q10664-mappedCitation-19839723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19839723 |
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