| http://purl.uniprot.org/citations/19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19842844 | http://www.w3.org/2000/01/rdf-schema#comment | "Epigenetic silencing of E-cadherin via aberrant methylation has been investigated in various human tumors, whereas evidence for elucidating mechanism underlying reduction of E-cadherin mRNA remains unclear in non-small cell lung cancer (NSCLC). The authors previously found that reduction of E-cadherin mRNA or protein expression has been frequently observed in NSCLC. In this study, the authors explore the contribution of E-cadherin methylation to the development and progression of NSCLC. The authors directly performed the bisulfite DNA sequencing to examine CpG methylation within the 5' CpG island of E-cadherin in 35 tumor and paired normal tissue specimens from patients with primary NSCLC. Then, the authors measured the level of E-cadherin mRNA by real-time quantitative polymerase chain reaction (PCR) analysis. Despite of reduction in E-cadherin mRNA by 65.7% (23/35) and presence of methylation by 28.6% (10/35) in tumors, the authors found no association of reduction of E-cadherin mRNA level with methylation of 19 sites from -181 to -9 bp located upstream from the translation start of E-cadherin in NSCLC. In conclusion, the authors provide no evidence for the presence of aberrant methylation sites of E-cadherin in tumors from patients with NSCLC, which can explain decrease of E-cadherin mRNA. Decrease in E-cadherin mRNA may be regulated by methylation-independent pathways in NSCLC."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.org/dc/terms/identifier | "doi:10.1080/01902140902770016"xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Lei Z."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Zhang H.T."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Liu R.Y."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/author | "Chen X.F."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/name | "Exp Lung Res"xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/pages | "541-553"xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/title | "Infrequently methylated event at sites -181 to -9 within the 5' CpG island of E-cadherin in non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19842844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19842844 |
| http://purl.uniprot.org/citations/19842844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19842844 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_A0A6C0N5X1-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_A5D8W4-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |
| http://purl.uniprot.org/uniprot/#_B3GN61-mappedCitation-19842844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19842844 |