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http://purl.uniprot.org/citations/19845142http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19845142http://www.w3.org/2000/01/rdf-schema#comment"

Background

Homer, known as a scaffolding protein that regulates postsynapse signaling in neurons, has been poorly explored in cardiac research. We show the fundamental properties of Homer 1 in mouse heart in association with cardiac ryanodine receptor (RyR), a binding protein of Homer 1.

Methods and results

Immunohistochemistry of adult mouse heart with Homer 1 antibody showed striated staining on Z-bands both in atria and ventricles. The interactions between Homer 1 and RyR were confirmed by co-immunoprecipitation assays. Immunostaining of adult isolated cardiomyocytes showed partial co-localization of both proteins. In neonatal primary cultures, targeting of Homer 1 preceded that of RyR in their Z-band arrangement.

Conclusions

Homer 1 binds to RyR in adult mouse heart and precedes RyR in Z-band arrangement in the early postnatal period."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/author"Kawano S."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/author"Kawaguchi S."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/author"Furuichi T."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/author"Shoji S."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/author"Sunamori M."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/name"J Med Dent Sci"xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/pages"103-108"xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/title"The fundamental properties of Homer 1 in association with cardiac ryanodine receptor in mouse heart."xsd:string
http://purl.uniprot.org/citations/19845142http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/19845142http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19845142
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