Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/19845668http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19845668http://www.w3.org/2000/01/rdf-schema#comment"

Background

Several cancer-related genes are silenced by promoter hypermethylation in skin cancers. However, to date the somatic epigenetic events that occur in cutaneous squamous cell carcinoma (SCC) tumorigenesis have not been well defined.

Objectives

To examine epigenetic abnormalities of FOXE1, a gene located on chromosome 9q22, a region frequently lost in SCC.

Methods

We investigated the methylation status of FOXE1 in 60 cases of cutaneous SCC by methylation-specific polymerase chain reaction, and comparatively examined mRNA and protein expression by real-time polymerase chain reaction and Western blot, respectively.

Results

We found a higher frequency of FOXE1 promoter hypermethylation in SCCs (55%), as compared with the adjacent uninvolved skin (12%) and blood control samples (9.5%). FOXE1 methylation was frequently seen in association with a complete absence of or downregulated gene expression. Treatment with the demethylating agent 5-Aza-2'-deoxycytidine resulted in profound reactivation of FOXE1 expression.

Conclusions

These results indicate that FOXE1 is a crucial player in development of cutaneous SCC."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2133.2009.09560.x"xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Visalli M."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Loddo S."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Teti D."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Venza I."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Venza M."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"De Grazia G."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/author"Tripodo B."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/name"Br J Dermatol"xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/pages"1093-1097"xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/title"FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/19845668http://purl.uniprot.org/core/volume"162"xsd:string
http://purl.uniprot.org/citations/19845668http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19845668
http://purl.uniprot.org/citations/19845668http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19845668
http://purl.uniprot.org/uniprot/#_O00358-mappedCitation-19845668http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19845668
http://purl.uniprot.org/uniprot/O00358http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19845668