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http://purl.uniprot.org/citations/19845952http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19845952http://www.w3.org/2000/01/rdf-schema#comment"

Background

A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (HLA) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different HLA-C alleles on rash associated with nevirapine in patients who started highly active anti-retroviral therapy (HAART) containing nevirapine in Thailand.

Results

A case-control study was carried out involving HIV-1 patients under treatment at Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand between March 2007 and March 2008. The study included all HIV/AIDS patients being treated with nevirapine-containing regimens. The study population comprised 287 HIV/AIDS patients of whom 248 were nevirapine-tolerant and 39 developed rash after nevirapine treatment. From the nevirapine-tolerant patients, 60 were selected as the control group on the basis of age, sex, and therapy history matched for nevirapine-induced rash cases. We observed significantly more HLA-Cw*04 alleles in nevirapine-induced rash cases than in nevirapine-tolerant group, with frequencies of 20.51% and 7.50%, respectively (P = 0.009). There were no significant differences between the rash and tolerant groups for other HLA-C alleles except for HLA-Cw*03 (P = 0.015).

Conclusion

This study suggests that HLA-Cw*04 is associated with rash in nevirapine treated Thais. Future screening of patients' HLA may reduce the number of nevirapine-induced rash cases, and patients with alleles associated with nevirapine-induced rash should be started on anti-retroviral therapy without nevirapine."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.org/dc/terms/identifier"doi:10.1186/1742-6405-6-22"xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Shioda T."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Nakayama E.E."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Uttayamakul S."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Rattanatham T."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Likanonsakul S."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Prasithsirikul W."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Feangvad S."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/author"Tunthanathip P."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/name"AIDS Res Ther"xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/pages"22"xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/title"HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients."xsd:string
http://purl.uniprot.org/citations/19845952http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/19845952http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19845952
http://purl.uniprot.org/citations/19845952http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19845952
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http://purl.uniprot.org/uniprot/#_A0A0A7C8P8-mappedCitation-19845952http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19845952
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