| http://purl.uniprot.org/citations/19846535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19846535 | http://www.w3.org/2000/01/rdf-schema#comment | "Killer immunoglobulin-like receptors (KIRs) are related to the activation and inhibition of NK cells and may play an important role in the innate response against infection with viruses such as hepatitis C virus (HCV). We examined whether the different combinations of KIRs with their HLA class I ligands influenced the response to combined treatment (pegylated alpha interferon and ribavirin) of patients infected by HCV. A total of 186 consecutive patients diagnosed with chronic HCV infection were analyzed. Seventy-seven patients exhibited HCV RNA levels at 6 months posttreatment and were called nonresponders (NR), while 109 cleared viral RNA and were named sustained viral responders (SVR). Patients were typed for HLA-B, HLA-Cw, KIR genes, and HCV genotype. In our study, the frequency of the KIR2DL2 allele was significantly increased in NR (P < 0.001; odds ratio [OR] = 1.95), as was the frequency of the KIR2DL2/KIR2DL2 genotype (P < 0.005; OR = 2.52). In contrast, the frequencies of the KIR2DL3 genotype (P < 0.001) and KIR2DL3/KIR2DL3 genotype (P < 0.05; OR = 0.54) were significantly increased in the SVR. Different combinations of KIR2DL2 and KIR2DL3 alleles with their ligands were analyzed. The frequency of the KIR2DL2/KIR2DL2-HLA-C1C2 genotype was significantly increased in the NR (P < 0.01; OR = 3.15). Additionally, we found a higher frequency of the KIR2DL3/KIR2DL3-HLA-C1C1 genotype in the SVR group (P < 0.05; OR = 0.33). These results were not affected by the HCV genotype. In conclusion, patients who carried the KIR2DL2/KIR2DL2-HLA-C1C2 genotype were less prone to respond to treatment. However, the KIR2DL3/KIR2DL3-HLA-C1C1 genotype clearly correlated with a satisfactory response to treatment, defined by the clearance of HCV RNA."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01285-09"xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Prieto J."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Perez R."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Lopez-Larrea C."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Diaz-Pena R."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Lopez-Vazquez A."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Martinez-Borra J."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Rodrigo L."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Melon S."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Vidal-Castineira J.R."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Alonso-Arias R."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/author | "Fernandez-Suarez J."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/pages | "475-481"xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/title | "Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/19846535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19846535 |
| http://purl.uniprot.org/citations/19846535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19846535 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-19846535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19846535 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-19846535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19846535 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-19846535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19846535 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-19846535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19846535 |