| http://purl.uniprot.org/citations/19846776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19846776 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with neurofibromatosis type 1 (NF1) carry approximately a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST). Although the molecular mechanisms underlying NF1 to MPNST malignant transformation remain unclear, alterations of both the RAS/RAF/MAPK and PI3K/AKT/mTOR signaling pathways have been implicated. In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 or Pten tumor suppressor genes. Only K-Ras activation in combination with a single Pten allele deletion led to 100% penetrable development of NF lesions and subsequent progression to MPNST. Importantly, loss or decrease in PTEN expression was found in all murine MPNSTs and a majority of human NF1-associated MPNST lesions, suggesting that PTEN dosage and its controlled signaling pathways are critical for transformation of NFs to MPNST. Using noninvasive in vivo PET-CT imaging, we demonstrated that FDG can be used to identify the malignant transformation in both murine and human MPNSTs. Our data suggest that combined inhibition of RAS/RAF/MAPK and PTEN/PI3K/AKT pathways may be beneficial for patients with MPNST."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0910398106"xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Dang J."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Mischel P.S."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Nakashima J."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Ao Y."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Parada L.F."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Sofroniew M.V."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Smith K.B."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Gregorian C."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Mellinghoff I.K."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Phelps M."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Lawson G."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Nghiemphu P.L."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Dry S.M."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/author | "Eilber F.C."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/pages | "19479-19484"xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/title | "PTEN dosage is essential for neurofibroma development and malignant transformation."xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19846776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19846776 |