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http://purl.uniprot.org/citations/19849849http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19849849http://www.w3.org/2000/01/rdf-schema#comment"

Background

Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of beta amyloid (Abeta) peptides. Abeta is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by beta-secretase and gamma-secretase.

Results

Here, we show that CD74, the invariant chain of class II major histocompatibility complex, interacts with APP and serves as a negative regulator of Abeta. CD74 resembles other APP interacters such as BRI2 and BRI3, since all of them reduce the level of Abeta. However, unlike BRIs, CD74 does not reduce the secretion of sAPPalpha or sAPPbeta. Interestingly, in HeLa cells, over expression of CD74 steers APP, but not Notch, to large vacuoles created by CD74.

Conclusion

Taken together, we propose that CD74 inhibits Abeta production by interacting with and derailing normal trafficking of APP."xsd:string
http://purl.uniprot.org/citations/19849849http://purl.org/dc/terms/identifier"doi:10.1186/1750-1326-4-41"xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/author"Matsuda Y."xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/author"Matsuda S."xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/author"D'Adamio L."xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/name"Mol Neurodegener"xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/pages"41"xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/title"CD74 interacts with APP and suppresses the production of Abeta."xsd:string
http://purl.uniprot.org/citations/19849849http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/19849849http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19849849
http://purl.uniprot.org/citations/19849849http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19849849
http://purl.uniprot.org/uniprot/P05067#attribution-1C147DDEE7935EC12E540939204B62E9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19849849
http://purl.uniprot.org/uniprot/P04233#attribution-1C147DDEE7935EC12E540939204B62E9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19849849
http://purl.uniprot.org/uniprot/P04233#attribution-9771755C09751E4AD18F431571FAFC48http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19849849
http://purl.uniprot.org/uniprot/Q9Y287#attribution-1C147DDEE7935EC12E540939204B62E9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19849849
http://purl.uniprot.org/uniprot/Q9NQX7#attribution-1C147DDEE7935EC12E540939204B62E9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19849849