| http://purl.uniprot.org/citations/19850923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19850923 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho GTPase family member RhoE inhibits RhoA/ROCK signaling to promote actin stress fiber and focal adhesion disassembly. We have previously reported that RhoE also inhibits cell cycle progression and Ras-induced transformation, specifically preventing cyclin D1 translation. Here we investigate the molecular mechanisms underlying those observations. RhoE inhibits the phosphorylation of the translational repressor 4E-BP1 in response to extracellular stimuli. However, RhoE does not affect the activation of mTOR, the major kinase regulating 4E-BP1 phosphorylation, as indicated by the phosphorylation levels of the mTOR substrate S6K, the dynamics of mTOR/Raptor association, and the observation that RhoE, as opposed to rapamycin, does not impair cellular growth. Interestingly, RhoE prevents the release of the eukaryotic initiation factor eIF4E from 4E-BP1, inhibiting cap-dependent translation. Accordingly, RhoE also inhibits the expression and the transcriptional activity of the eIF4E target c-Myc. Consistent with its crucial role in cell proliferation, we show that eIF4E can rescue both cell cycle progression and Ras-induced transformation in RhoE-expressing cells, indicating that the inhibition of eIF4E function is critical to mediate the anti-proliferative effects of RhoE."xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.050120"xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/author | "Villalonga P."xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/author | "Fernandez de Mattos S."xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/pages | "35287-35296"xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/title | "RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation."xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19850923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19850923 |
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| http://purl.uniprot.org/uniprot/#_Q13541-mappedCitation-19850923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19850923 |
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| http://purl.uniprot.org/uniprot/#_Q53RZ3-mappedCitation-19850923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19850923 |