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http://purl.uniprot.org/citations/19853563http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19853563http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19853563http://www.w3.org/2000/01/rdf-schema#comment"Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.org/dc/terms/identifier"doi:10.1016/j.devcel.2009.08.008"xsd:string
http://purl.uniprot.org/citations/19853563http://purl.org/dc/terms/identifier"doi:10.1016/j.devcel.2009.08.008"xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Kohara Y."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Kohara Y."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Vakonakis I."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Vakonakis I."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Avery L."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Avery L."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Langenhan T."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Langenhan T."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Promel S."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Promel S."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Russ A.P."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Russ A.P."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Waller-Evans H."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Waller-Evans H."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Schnabel R."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Schnabel R."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Esmaeili B."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Esmaeili B."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Hennig C."xsd:string
http://purl.uniprot.org/citations/19853563http://purl.uniprot.org/core/author"Hennig C."xsd:string