| http://purl.uniprot.org/citations/19854952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19854952 | http://www.w3.org/2000/01/rdf-schema#comment | "The white gene, which is responsible for eye pigmentation, is widely used to study position effects in Drosophila. As a result of insertion of P-element vectors containing mini-white without enhancers into random chromosomal sites, flies with different eye color phenotypes appear, which is usually explained by the influence of positive/negative regulatory elements located around the insertion site. We found that, in more than 70% of cases when mini-white expression was subject to positive position effects, deletion of the white promoter had no effect on eye pigmentation; in these cases, the transposon was inserted into the transcribed regions of genes. Therefore, transcription through the mini-white gene could be responsible for high levels of its expression in most of chromosomal sites. Consistently with this conclusion, transcriptional terminators proved to be efficient in protecting mini-white expression from positive position effects. On the other hand, the best characterized Drosophila gypsy insulator was poorly effective in terminating transcription and, as a consequence, only partially protected mini-white expression from these effects. Thus, to ensure maximum protection of a transgene from position effects, a perfect boundary/insulator element should combine three activities: to block enhancers, to provide a barrier between active and repressed chromatin, and to terminate transcription."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkp877"xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Pomerantseva E."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Georgiev P."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Maksimenko O."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Golovnin A."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Parshikov A."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/author | "Silicheva M."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/pages | "39-47"xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/title | "Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding."xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19854952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19854952 |
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