| http://purl.uniprot.org/citations/19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19855082 | http://www.w3.org/2000/01/rdf-schema#comment | "KLRG1 is an inhibitory receptor expressed on a subset of mature T and NK cells. Recently, E-, N-, and R-cadherin have been identified as ligands for KLRG1. Cadherins are a large family of transmembrane or membrane-associated glycoproteins that were thought to only bind specifically to other cadherins to mediate specific cell-to-cell adhesion in a Ca(2+)-dependent manner. The consequences of cadherin KLRG1 molecular interactions are not well characterized. Here, we report that the first 2 extracellular domains of cadherin are sufficient to initiate a KLRG1-dependent signaling. We also demonstrate that KLRG1 engagement inhibits cadherin-dependent cellular adhesion and influences dendritic cell secretion of inflammatory cytokines, thereby exerting immunosuppressive effects. Consistent with this, engagement of cadherin by KLRG1 molecule induces cadherin tyrosine phosphorylation. Therefore, KLRG1/cadherin interaction leads to the generation of a bidirectional signal in which both KLRG1 and cadherin activate downstream signaling cascades simultaneously. Taken together, our results provide novel insights on how KLRG1 and E-cadherin interactions are integrated to differentially regulate not only KLRG1(+) cells, but also E-cadherin-expressing cells, such as dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-06-228353"xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/author | "Fugere C."xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/author | "Banh C."xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/author | "Brossay L."xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/pages | "5299-5306"xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/title | "Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling."xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19855082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19855082 |
| http://purl.uniprot.org/citations/19855082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19855082 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW5-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_O88713-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_G3UWS6-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_G3V014-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_P40201-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_P09803-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q3UQG5-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q4KML8-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q3USG6-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q9CRD9-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q8C7Q2-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |
| http://purl.uniprot.org/uniprot/#_Q8C9F3-mappedCitation-19855082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855082 |