| http://purl.uniprot.org/citations/19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19855844 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMicro RNAs are small, non-coding, single-stranded RNAs that negatively regulate gene expression at the post-transcriptional level. Since miR-143 was found to be down-regulated in prostate cancer cells, we wanted to analyze its expression in human prostate cancer, and test the ability of miR-43 to arrest prostate cancer cell growth in vitro and in vivo.ResultsExpression of miR-143 was analyzed in human prostate cancers by quantitative PCR, and by in situ hybridization. miR-143 was introduced in cancer cells in vivo by electroporation. Bioinformatics analysis and luciferase-based assays were used to determine miR-143 targets. We show in this study that miR-143 levels are inversely correlated with advanced stages of prostate cancer. Rescue of miR-143 expression in cancer cells results in the arrest of cell proliferation and the abrogation of tumor growth in mice. Furthermore, we show that the effects of miR-143 are mediated, at least in part by the inhibition of extracellular signal-regulated kinase-5 (ERK5) activity. We show here that ERK5 is a miR-143 target in prostate cancer.ConclusionsmiR-143 is as a new target for prostate cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0007542"xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Villalba M."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Fritz V."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Iborra F."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Fernandez P.L."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Henriquet C."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Fajas L."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Apparailly F."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Culine S."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Avances C."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/author | "Clape C."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/pages | "e7542"xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/title | "miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice."xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/19855844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19855844 |
| http://purl.uniprot.org/citations/19855844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19855844 |
| http://purl.uniprot.org/uniprot/#_B4DI23-mappedCitation-19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855844 |
| http://purl.uniprot.org/uniprot/#_Q13164-mappedCitation-19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855844 |
| http://purl.uniprot.org/uniprot/#_Q32MU3-mappedCitation-19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855844 |
| http://purl.uniprot.org/uniprot/#_Q61575-mappedCitation-19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855844 |
| http://purl.uniprot.org/uniprot/#_Q5NCN8-mappedCitation-19855844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19855844 |