| http://purl.uniprot.org/citations/19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19858221 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Galactose residues on N-glycans have been implicated to be involved in growth regulation of cells. In the present study we compared the galactosylation of cell surface N-glycans of mouse Balb/3T3 cells between 30 and 100% densities and found the beta-1,4-galactosylation of N-glycans increases predominantly in a 100-kDa protein band on lectin blot analysis in combination with digestions by diplococcal beta-galactosidase and N-glycanase. When cells at 100% density were treated with jack bean beta-galactosidase, the incorporation of 5-bromodeoxyuridine into the cells was stimulated in a dose-dependent manner, suggesting the involvement of the galactose residues in growth regulation of cells. A galactose-binding protein was isolated from the plasma membranes of cells at 100% density by affinity chromatography using an asialo-transferrin-Sepharose column and found to be galectin-3 as revealed by mass spectrometric analysis. The addition of recombinant galectin-3 into cells at 50% density inhibited the incorporation of 5-bromodeoxyuridine in a dose-dependent manner, but the inhibition was prevented with haptenic sugar. An immunocytochemical study showed that galectin-3 is present at the surface of cells at 100% density but not at 30% density where it locates inside the cells. Several glycoproteins bind to a galectin-3-immobilized column, a major of which was identified as vascular cell adhesion molecule (VCAM)-1. Immunocytochemical studies showed that some galectin-3 and VCAM-1 co-localize at the surface of cells at 100% density, indicating that the binding of galectin-3 secreted from cells to VCAM-1 is one of the pathways involved in the growth regulation of Balb/3T3 cells."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.063339"xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Ikekita M."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Tadokoro T."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Hamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/author | "Nakatani R."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/pages | "35556-35563"xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/title | "Involvement of Galectin-3 with vascular cell adhesion molecule-1 in growth regulation of mouse BALB/3T3 cells."xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19858221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19858221 |
| http://purl.uniprot.org/citations/19858221 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19858221 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0I9-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_D3YVT4-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_D3Z5M3-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFP9-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRE5-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_F6UAC8-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |
| http://purl.uniprot.org/uniprot/#_F6XU19-mappedCitation-19858221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19858221 |