| http://purl.uniprot.org/citations/19860590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19860590 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematological disorders like Aplastic anemia are quite frequent in Pakistan. Human leukocyte antigen (HLA) system, have been implicated in the development of Aplastic anemia in various population-based studies, The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptibility to Aplastic anemia in Pakistani patients. HLA A*, B* and DRB1* alleles were analyzed, in 61 Pakistani patients (Females n = 22, Males n = 39) and the control group consisted of 200 ethnically matched individuals (Females n = 89, Males n = 111). The allele frequency of DRB1*15 was found significantly higher in patients 0.36 (p = 0.001 with odds ratio = 1.97), as compared to the controls 0.212. Although DRB1*03 percent frequency was significantly higher in controls 0.175 (p = 0.023) with odds ratio = 0.514, as compared to patients 0.106.Therefore DRB1*15 emerged as a susceptible allele and DRB1*03 as a protective allele in Pakistani Aplastic anemia patients and control samples. No significant difference was found in allele frequencies of other HLA class I and HLA class II alleles for both patients and controls. Three haplotypes A*02 B*40 DRB1*15 (p = 0.021), A*31 B*51 DRB1*13 (p = 0.12) and A*33 B*58 DRB1*15 (p = 0.000) showed significant variations in the two groups."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.org/dc/terms/identifier | "doi:10.3109/08820130903271415"xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Munir S."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Rehman S."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Ahmed P."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Mehmood T."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Saba N."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/author | "Khalilullah"xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/name | "Immunol Invest"xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/pages | "812-819"xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/title | "The frequency of HLA class I and II alleles in Pakistani patients with aplastic anemia."xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19860590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19860590 |
| http://purl.uniprot.org/citations/19860590 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19860590 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19860590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860590 |
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