| http://purl.uniprot.org/citations/19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19860744 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-level alloreactivity between mother and fetus may provide stimulation for fetal T helper type 1 (Th1) cell immune maturation. This study explored the effects of human leucocyte antigen (HLA) mismatch on materno-fetal interactions detected as cytokine responses and lymphoproliferation in mixed lymphocyte reactions, and whether this was altered in allergic women (n = 62) who have a Th2 propensity compared with non-allergic women (n = 65). HLA-DRbeta1 mismatch was associated with significantly increased Th1 interferon (IFN)-gamma, Th2 interleukin (IL)-13 and lymphoproliferative responses by both mothers and fetuses. Allergic women showed significantly lower IFN-gamma Th1 production in response to HLA-DRbeta1 mismatch. The infants of these women also showed significantly lower IL-10 and lower IFN-gamma production relative to IL-13. Both HLA-DRbeta1 mismatch and maternal allergy had significant independent effects on maternal IFN-gamma Th1 responses. Maternal allergy modifies HLA-mediated alloreactivity between the mother and the fetus, reducing Th1 activation. This may affect the cytokine milieu at the materno-fetal interface and could be implicated in the attenuated Th1 responses observed commonly in infants of atopic mothers."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2009.04042.x"xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Smith L."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Christiansen F.T."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Witt C.S."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Dunstan J.A."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Prescott S.L."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/author | "Breckler L.A."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/pages | "65-72"xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/title | "Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy."xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/19860744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19860744 |
| http://purl.uniprot.org/citations/19860744 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19860744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
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| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-19860744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19860744 |
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