| http://purl.uniprot.org/citations/19861119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19861119 | http://www.w3.org/2000/01/rdf-schema#comment | "The orphan nuclear receptor (NR) Nurr1 is expressed in the developing and adult nervous system and is also induced as an immediate early gene in a variety of cell types. In silico analysis of human promoters identified fatty acid binding protein 5 (FABP5), a protein shown to enhance retinoic acid-mediated PPARbeta/delta signaling, as a potential Nurr1 target gene. Nurr1 has previously been implicated in retinoid signaling via its heterodimerization partner RXR. Since NRs are commonly involved in cross-regulatory control we decided to further investigate the regulatory relationship between Nurr1 and FABP5. FABP5 expression was up-regulated by Nurr1 and other NR4A NRs in HEK293 cells, and Nurr1 was shown to activate and bind to the FABP5 promoter, supporting that FABP5 is a direct downstream target of NR4A NRs. We also show that the RXR ligand docosahexaenoic acid (DHA) can induce nuclear translocation of FABP5. Moreover, via up-regulation of FABP5 Nurr1 can enhance retinoic acid-induced signaling of PPARbeta/delta and DHA-induced activation of RXR. We also found that other members of the NR4A orphan NRs can up-regulate FABP5. Thus, our findings suggest that NR4A orphan NRs can influence signaling events of other NRs via control of FABP5 expression levels."xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.10.116"xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/author | "Joodmardi E."xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/author | "Perlmann T."xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/author | "Volakakis N."xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/pages | "1186-1191"xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/title | "NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5."xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://purl.uniprot.org/core/volume | "390"xsd:string |
| http://purl.uniprot.org/citations/19861119 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19861119 |
| http://purl.uniprot.org/citations/19861119 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19861119 |
| http://purl.uniprot.org/uniprot/#_E7DVW5-mappedCitation-19861119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19861119 |
| http://purl.uniprot.org/uniprot/#_Q01469-mappedCitation-19861119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19861119 |
| http://purl.uniprot.org/uniprot/E7DVW5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19861119 |
| http://purl.uniprot.org/uniprot/Q01469 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19861119 |