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http://purl.uniprot.org/citations/19861252http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19861252http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the effect of p38 mitogen-activated protein kinase (p38MAPK) on the expression of COX-2 and caspase-3 in the substania nigra (SN) of mice with MPTP-induced Parkinson disease (PD).

Methods

C57BL/CN mice were treated with MPTP to prepare a subacute PD model, and their behavioral changes following the treatment were observed. Immunohistochemistry and Western blotting were performed to detect the expression of tyrosine hydroxylase (TH), COX-2 and phosphorylation of P38MAPK in the SN and their changes following treatment with SB203580, a specific inhibitor of P38MAPK.

Results

The 7-day model group showed typical symptoms of PD with decrements of TH-positive neurons and TH protein level in the SN of the midbrain by about 65% and 75%, respectively (P<0.01). In the 3-day model group, the COX-2-, caspase-3- and phosphorylated P38MAPK-immunoreactive cells and their protein levels in the SN increased markedly with obvious loss of TH-positive neurons. Administration of SB203580 obviously lessened the above changes (P<0.01).

Conclusion

P38MAPK regulates the inflammation and apoptosis in the SN of the mouse model of subacute PD, and SB203580 may provide some neuroprotective effect."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Wang Q."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Zhang Y.X."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Zhang Z.F."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Wang Y.S."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Wei Z.F."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/author"Ma L.R."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/name"Nan Fang Yi Ke Da Xue Xue Bao"xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/pages"2010-2013"xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/title"[P38MAPK pathway regulates COX-2 and caspase-3 expression in a mouse model of Parkinson disease]."xsd:string
http://purl.uniprot.org/citations/19861252http://purl.uniprot.org/core/volume"29"xsd:string
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