| http://purl.uniprot.org/citations/19864465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19864465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19864465 | http://www.w3.org/2000/01/rdf-schema#comment | "The heat-shock response is characterized by the expression of a set of classical heat-shock genes, and is regulated by heat-shock transcription factor 1 (HSF1) in mammals. However, comprehensive analyses of gene expression have revealed very large numbers of inducible genes in cells exposed to heat shock. It is believed that HSF1 is required for the heat-inducible expression of these genes although HSF2 and HSF4 modulate some of the gene expression. Here, we identified a novel mouse HSF3 (mHSF3) translocated into the nucleus during heat shock. However, mHSF3 did not activate classical heat-shock genes such as Hsp70. Remarkably, overexpression of mHSF3 restored the expression of nonclassical heat-shock genes such as PDZK3 and PROM2 in HSF1-null mouse embryonic fibroblasts (MEFs). Although down-regulation of mHSF3 expression had no effect on gene expression or cell survival in wild-type MEF cells, it abolished the moderate expression of PDZK3 mRNA and reduced cell survival in HSF1-null MEF cells during heat shock. We propose that mHSF3 represents a unique HSF that has the potential to activate only nonclassical heat-shock genes to protect cells from detrimental stresses."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-07-0639"xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-07-0639"xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.E09-07-0639"xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Katoh T."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Katoh T."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Oshima K."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Oshima K."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Nakai A."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Nakai A."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Tan K."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Tan K."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Inouye S."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Inouye S."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Hayashida N."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Hayashida N."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Shinkawa T."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Shinkawa T."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Takii R."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Takii R."xsd:string |
| http://purl.uniprot.org/citations/19864465 | http://purl.uniprot.org/core/author | "Prakasam R."xsd:string |