http://purl.uniprot.org/citations/19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19866343 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionAberrant signaling within and between B and T cells, considered to be central in systemic lupus erythematosus (SLE), could depend on enhanced CD40-CD154 activation. As a result, autoreactive B cells, normally anergic, differentiate and secrete antibodies attacking several normal tissues. Thus restorating B cell homeostasis might help control this disease. In this study, two facets of SLE B cells were investigated, namely their in vitro response to CD40-CD154 and the effect of treatment with human immunoglobulins for intravenous use (IVIg).Materials and methodsBlood samples from SLE patients and healthy volunteers were obtained and used to isolate B cells, which were activated through CD40 in the presence or absence of IVIg. The phenotype, proliferation, and differentiation of the SLE B cells were determined and compared with those of control B cells using flow cytometry and standard ELISA.ResultsIn this model, CD40-activated SLE B cells, as control B cells, proliferated and differentiated and were characterized by the emergence of CD19(lo)CD38(++)CD138(+)CD27(++) cells. IVIg treatment of the CD40-activated SLE B cells resulted in higher differentiation, characterized by increased secretion rates of IgG and IgM, as reported previously for control B cells.ConclusionsTaken as a whole, such accelerated differentiation of CD40-activated B cells suggests that IVIg may participate in re-equilibration of the antibody repertoire by replacing pathological antibodies by de novo harmless antibodies."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00005-009-0048-3"xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Cote S."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Jacques A."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Boire G."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Neron S."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Racine C."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "de Brum-Fernandes A.J."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/author | "Dussault N."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/name | "Arch Immunol Ther Exp (Warsz)"xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/pages | "447-458"xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/title | "CD40-activated B cells from patients with systemic lupus erythematosus can be modulated by therapeutic immunoglobulins in vitro."xsd:string |
http://purl.uniprot.org/citations/19866343 | http://purl.uniprot.org/core/volume | "57"xsd:string |
http://purl.uniprot.org/citations/19866343 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19866343 |
http://purl.uniprot.org/citations/19866343 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19866343 |
http://purl.uniprot.org/uniprot/#_B2R880-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_B4DMR7-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_B4DRQ9-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_B4E006-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_P18827-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_Q53H42-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_P28907-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |
http://purl.uniprot.org/uniprot/#_P26842-mappedCitation-19866343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19866343 |