| http://purl.uniprot.org/citations/19874202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19874202 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene targeting of the p50 and p52 subunits of NF-kappaB has shown that NF-kappaB plays a critical role in osteoclast differentiation. However, the molecular mechanism by which NF-kappaB regulates osteoclast differentiation is still unclear. To address this issue, we analyzed alymphoplasia (aly/aly) mice in which the processing of p100 to p52 does not occur owing to an inactive form of NF-kappaB-inducing kinase (NIK). Aly/aly mice showed a mild osteopetrosis with significantly reduced osteoclast numbers. RANKL-induced osteoclastogenesis from bone marrow cells of aly/aly mice also was suppressed. RANKL still induced the degradation of I kappaB alpha and activated classical NF-kappaB, whereas processing of p100 to p52 was abolished by the aly/aly mutation. Moreover, RANKL-induced expression of NFATc1 was impaired in aly/aly bone marrow. Overexpression of constitutively active IKK alpha or p52 restored osteoclastogenesis in aly/aly cells. Finally, transfection of either wild-type p100, p100 Delta GRR that cannot be processed to p52, or p52 into NF-kappaB 2-deficient cells followed by RANKL treatment revealed a strong correlation between the number of osteoclasts induced by RANKL and the ratio of p52 to p100 expression. Our data provide a new finding for a previously unappreciated role for NF-kappaB in osteoclast differentiation."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.org/dc/terms/identifier | "doi:10.1359/jbmr.091032"xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Aoki K."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Maruyama T."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Shin M."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Nakao K."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Fukushima H."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Doi T."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Ohya K."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Jimi E."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Alles N."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Weih F."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/author | "Hosokawa R."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/pages | "1058-1067"xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/title | "Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation."xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/19874202 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19874202 |
| http://purl.uniprot.org/citations/19874202 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19874202 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVZ8-mappedCitation-19874202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19874202 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW53-mappedCitation-19874202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19874202 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-19874202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19874202 |