| http://purl.uniprot.org/citations/19874716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19874716 | http://www.w3.org/2000/01/rdf-schema#comment | "The E2F gene family appears to regulate the proliferation and differentiation of events that are required for adipogenesis. Pref-1 is a transmembrane protein that inhibits adipocyte differentiation in 3T3-L1 cells. In this study, we found that the expression of pref-1 is regulated by the transcription factor E2F1. The expression of pref-1 and E2F1 was strongly induced in preadipocytes and at the late differentiation stage. Using luciferase reporter assay, ChIP assay and EMSA, we found that the -211/-194 region of the pref-1 promoter is essential for the binding of E2F1 as well as E2F1-dependent transcriptional activation. Knockdown of E2F1 reduced both pref-1 promoter activity and the level of pref-1 mRNA. Taken together, our data suggest that transcriptional activation of pref-1 is stimulated by E2F1 protein in adipocytes."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.org/dc/terms/identifier | "doi:10.5483/bmbrep.2009.42.10.691"xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/author | "Yun C.H."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/author | "Moon Y.S."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/author | "Shen Y.N."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/name | "BMB Rep"xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/pages | "691-696"xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/title | "Transcriptional activation of pref-1 by E2F1 in 3T3 L1 cells."xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/19874716 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19874716 |
| http://purl.uniprot.org/citations/19874716 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19874716 |
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| http://purl.uniprot.org/uniprot/#_Q09163-mappedCitation-19874716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19874716 |
| http://purl.uniprot.org/uniprot/#_Q61501-mappedCitation-19874716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19874716 |
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