http://purl.uniprot.org/citations/19874820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19874820 | http://www.w3.org/2000/01/rdf-schema#comment | "The abundant heterogeneous nuclear ribonucleoprotein M (hnRNP M) is able to associate with early spliceosomes and to influence splicing patterns of specific pre-mRNAs. Here, by a combination of immunoprecipitation and pull-down assays, we have identified PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb), two highly related proteins involved in transcription and RNA processing, as new binding partners of hnRNP M. HnRNP M was found to co-localize with PSF within a subset of nuclear paraspeckles and to largely co-fractionate with PSF and p54(nrb) in biochemical nuclear matrix preparations. In cells transfected with an alternatively spliced preprotachykinin (PPT) minigene expression of hnRNP M promoted exon skipping while expression of PSF favours exon inclusion. The latter effect was reverted specifically by co-expressing the full length hnRNP M or a deletion mutant capable of interaction with PSF and p54(nrb). Together our data provide new insights and some functional implications on the hnRNP M network of interactions."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.10.021"xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/author | "Marko M."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/author | "Guialis A."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/author | "Patrinou-Georgoula M."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/author | "Leichter M."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/pages | "390-400"xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/title | "hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures."xsd:string |
http://purl.uniprot.org/citations/19874820 | http://purl.uniprot.org/core/volume | "316"xsd:string |
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