| http://purl.uniprot.org/citations/19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19875813 | http://www.w3.org/2000/01/rdf-schema#comment | "WNK kinase is a serine/threonine kinase that plays an important role in electrolyte homeostasis. WNK4 significantly inhibits the surface expression of the sodium chloride co-transporter (NCC) by enhancing the degradation of NCC through a lysosomal pathway, but the mechanisms underlying this trafficking are unknown. Here, we investigated the effect of the lysosomal targeting receptor sortilin on NCC expression and degradation. In Cos-7 cells, we observed that the presence of WNK4 reduced the steady-state amount of NCC by approximately half. Co-transfection with truncated sortilin (a dominant negative mutant) prevented this WNK4-induced reduction in NCC. NCC immunoprecipitated with both wild-type sortilin and, to a lesser extent, truncated sortilin. Immunostaining revealed that WNK4 increased the co-localization of NCC with the lysosomal marker cathepsin D, and NCC co-localized with wild-type sortilin, truncated sortilin, and WNK4 in the perinuclear region. These findings suggest that WNK4 promotes NCC targeting to the lysosome for degradation via a mechanism involving sortilin."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2008121275"xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Cai H."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Guggino W.B."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Gu D."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Zhuang J."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/author | "Cebotaru L."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/pages | "82-92"xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/title | "WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway."xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19875813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19875813 |
| http://purl.uniprot.org/citations/19875813 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19875813 |
| http://purl.uniprot.org/uniprot/#_A8KAQ3-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/#_B4DXG4-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/#_Q99523-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/#_L8E783-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/#_P55017-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/#_Q96J92-mappedCitation-19875813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/L8E783 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19875813 |
| http://purl.uniprot.org/uniprot/B4DXG4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19875813 |