| http://purl.uniprot.org/citations/19877275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19877275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19877275 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise planar cell polarity (PCP) is critical for the development of multiple organ systems in animals. A group of core-PCP proteins are recognized to play crucial roles in convergent extension and other PCP-related processes in mammals. However, the functions of another group of PCP-regulating proteins, the PCP-effector proteins, are yet to be fully studied. In this study, the generation and characterization of a mouse mutant for the PCP effector gene Fuzzy (Fuz) is reported. Fuz homozygous mutants are embryonically lethal, with multiple defects including neural tube defects, abnormal dorsal/ventral patterning of the spinal cord, and defective anterior/posterior patterning of the limb buds. Fuz mutants also exhibit abnormal Hedgehog (Hh) signaling and inefficient proteolytic processing of Gli3. Finally, a significant decrease in cilia was found in Fuz homozygous mutants. In conclusion, Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.22130"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.22130"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Liu A."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Liu A."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Zeng H."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Heydeck W."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/author | "Heydeck W."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/name | "Dev. Dyn."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/name | "Dev. Dyn."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/pages | "3035-3042"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/pages | "3035-3042"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/title | "Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/title | "Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse."xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/volume | "238"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://purl.uniprot.org/core/volume | "238"xsd:string |
| http://purl.uniprot.org/citations/19877275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19877275 |
| http://purl.uniprot.org/citations/19877275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19877275 |
| http://purl.uniprot.org/citations/19877275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19877275 |
| http://purl.uniprot.org/citations/19877275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19877275 |