| http://purl.uniprot.org/citations/19879147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19879147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19879147 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular underpinnings of the oocyte-to-embryo transition are poorly understood. Here we show that two protein tyrosine phosphatase-like (PTPL) family proteins, EGG-4 and EGG-5, are required for key events of the oocyte-to-embryo transition in Caenorhabditis elegans. The predicted EGG-4 and EGG-5 amino acid sequences are 99% identical and their functions are redundant. In embryos lacking EGG-4 and EGG-5, we observe defects in meiosis, polar body formation, the block to polyspermy, F-actin dynamics, and eggshell deposition. During oogenesis, EGG-4 and EGG-5 assemble at the oocyte cortex with the previously identified regulators or effectors of the oocyte-to-embryo transition EGG-3, CHS-1, and MBK-2 [1, 2]. All of these molecules share a complex interdependence with regards to their dynamics and subcellular localization. Shortly after fertilization, EGG-4 and EGG-5 are required to properly coordinate a redistribution of CHS-1 and EGG-3 away from the cortex during meiotic anaphase I. Therefore, EGG-4 and EGG-5 are not only required for critical events of the oocyte-to-embryo transition but also link the dynamics of the regulatory machinery with the advancing cell cycle."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.09.015"xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.09.015"xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Maruyama R."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Maruyama R."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Singson A."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Singson A."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Hang J.S."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Hang J.S."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Klancer R."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Klancer R."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Parry J.M."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Parry J.M."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Velarde N.V."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Velarde N.V."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Druzhinina M.K."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Druzhinina M.K."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Lefkovith A.J."xsd:string |
| http://purl.uniprot.org/citations/19879147 | http://purl.uniprot.org/core/author | "Lefkovith A.J."xsd:string |