| http://purl.uniprot.org/citations/19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19879597 | http://www.w3.org/2000/01/rdf-schema#comment | "High-resolution HLA-DRB1 genotyping was performed in 97 OCB-positive and 68 OCB-negative cases with demyelinating disease to determine the influence of HLA-DRB1 alleles on the presence of OCB in a West Australian multiple sclerosis (MS) cohort. Carriage of the HLA-DRB1*1501 allele was associated with both OCB-positive and OCB-negative MS compared with controls, but more strongly with the OCB-positive group, and increased the likelihood of having OCB 2.1-fold with evidence of a dominant dose-effect. The HLA-DRB1*0301 allele was negatively correlated with OCB, with all homozygotes OCB-negative, suggesting a possible recessive protective effect of HLA-DRB1*0301. There was no significant correlation between OCB and the DRB1*04 alleles which have been associated with OCB-negative MS in previous Swedish and Japanese studies. Evidence of allelic interactions was found with HLA-DRB1*1501/*1301 heterozygotes having a reduced frequency of OCB and HLA-DRB1*0301/*0401 heterozygotes all being OCB-negative. These findings confirm the strong association between HLA-DRB1*1501 and OCB which has been found in other populations but indicate that the influence of other HLA-DRB1 alleles varies in different populations. Our study is the first to show that HLA-DRB1 allele interactions and dose-effects influence the frequency of OCB."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jns.2009.10.005"xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Qiu W."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "James I."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Wu J.S."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Joseph J."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Christiansen F.T."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Carroll W.M."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Kermode A.G."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Castley A."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/author | "Mastaglia F.L."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/name | "J Neurol Sci"xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/pages | "63-67"xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/title | "Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort."xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/19879597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19879597 |
| http://purl.uniprot.org/citations/19879597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19879597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879597 |