| http://purl.uniprot.org/citations/19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19879913 | http://www.w3.org/2000/01/rdf-schema#comment | "Recurrent lymphocytic meningitis (RLM) is a rare illness caused mostly by herpes simplex virus type 2 (HSV-2). Predisposing factors are not known. Deficiencies in immunoglobulin (Ig) G subclasses 1 (IgG1) and 3 (IgG3) and complement protein C4 are associated with susceptibility to and persistence of bacterial and viral infections. Selected HLA and mannose-binding lectin (MBL) alleles have previously been associated with recurrent genital herpes or herpetic meningitis. We assessed the frequencies of low IgG1 and IgG3, their allotypes (Gm), and HLA-A*, -B*, -DRB1*, and MBL2 alleles, as well as deficiencies in C4A and C4B genes, as potential predisposing factors for HSV-2-associated RLM. The level of IgG1 was lower (p = 0.009) and the frequency of low IgG1 was higher (p < 0.001) in patients than in controls. Furthermore, the risk for a new meningitis episode was increased in patients with low IgG1 (incident ratio 2.05). HLA-DRB1*01 (p = 0.009) and -B*27 (p = 0.050) were more common among patients than controls. We conclude that HLA-DRB1*01 and -B*27 alleles and low plasma IgG1 levels may be significant risk factors for RLM."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2009.10.014"xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Lokki M.L."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Kalso E."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Seppala I."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Seppanen M."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Aittoniemi J."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Farkkila M."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Kautiainen H."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Valtonen V."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/author | "Kallio-Laine K."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/pages | "179-181"xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/title | "HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis."xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/19879913 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19879913 |
| http://purl.uniprot.org/citations/19879913 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-19879913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19879913 |