| http://purl.uniprot.org/citations/19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19880493 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternatively activated macrophages play an important role in host defense in the context of a T helper type 2 (Th2) microenvironment such as parasitic infection. However, the role of these macrophages during secondary challenge with Th1 pathogens is poorly defined. In this study, thioglycollate-elicited mouse peritoneal macrophages were treated with interleukin-4 (IL-4) or IL-13 in vitro and challenged with Neisseria meningitidis. After 8 to 12 hours of IL-4 pretreatment, the nonopsonic phagocytic uptake of N meningitidis was markedly reduced, depending on the common IL-4Ralpha chain, but independent of Scavenger receptor A and macrophage receptor with collagenous structure (MARCO), 2 known receptors for N meningitidis. Inhibition of phagocytosis extended to several other microbial particles, zymosan, and other bacteria. Concomitantly, IL-4 potentiated the secretion of proinflammatory cytokines, after additional bacterial stimulation, which depended on the MyD88 signaling pathway. Similar results were obtained after intraperitoneal stimulation of IL-4 and N meningitidis in vivo. Further in vitro studies showed a striking correlation with inhibition of Akt phosphorylation and stimulation of the mitogen-activated protein kinase pathway; inhibition of phagocytosis was associated with inhibition of phagosome formation. These findings are relevant to host defense in mixed infections within a Th2 microenvironment and shed light on immunologic functions associated with alternative priming and full activation of macrophages."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-08-236711"xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/author | "Mukhopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/author | "Gordon S."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/author | "Herbein G."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/author | "Varin A."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/pages | "353-362"xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/title | "Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion."xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/19880493 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19880493 |
| http://purl.uniprot.org/citations/19880493 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A087WS94-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW1-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPZ6-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A2RT24-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_A2VCP1-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |
| http://purl.uniprot.org/uniprot/#_F6SPW1-mappedCitation-19880493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880493 |