| http://purl.uniprot.org/citations/19880523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19880523 | http://www.w3.org/2000/01/rdf-schema#comment | "Serine-threonine kinase receptor-associated protein (STRAP) interacts with transforming growth factor beta (TGF-beta) receptors and inhibits TGF-beta signaling. Here, we identify STRAP as an interacting partner of ASK1 (apoptosis signal-regulating kinase 1). The association between ASK1 and STRAP is mediated through the C-terminal domain of ASK1 and the fourth and sixth WD40 repeats of STRAP. Using cysteine-to-serine amino acid substitution mutants of ASK1 (C1005S, C1351S, C1360S, and C1351S/C1360S) and STRAP (C152S, C270S, and C152S/C270S), we demonstrated that Cys(1351) and Cys(1360) of ASK1 and Cys(152) and Cys(270) of STRAP are required for ASK1-STRAP binding. ASK1 phosphorylated STRAP at Thr(175) and Ser(179), suggesting a potential role for STRAP phosphorylation in ASK1 activity regulation. Expression of wild-type STRAP, but not STRAP mutants (C152S/C270S and T175A/S179A), inhibited ASK1-mediated signaling to both JNK and p38 kinases by stabilizing complex formation between ASK1 and its negative regulators, thioredoxin and 14-3-3, or decreasing complex formation between ASK1 and its substrate MKK3. In addition, STRAP suppressed H(2)O(2)-mediated apoptosis in a dose-dependent manner by inhibiting ASK1 activity through direct interaction. These results suggest that STRAP can act as a negative regulator of ASK1."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.045229"xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/author | "Jung H."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/author | "Ha H."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/author | "Seong H.A."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/author | "Manoharan R."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/pages | "54-70"xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/title | "Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction."xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/19880523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19880523 |
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