| http://purl.uniprot.org/citations/19880526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19880526 | http://www.w3.org/2000/01/rdf-schema#comment | "Williams-Beuren syndrome (WBS), an autosomal dominant genetic disorder, is characterized by a unique cognitive profile and craniofacial defects. WBS results from a microdeletion at the chromosomal location 7q11.23 that encompasses the genes encoding the members of TFII-I family of transcription factors. Given that the haploinsufficiency for TFII-I is causative to the craniofacial phenotype in humans, we set out to analyze the effect of post-transcriptional silencing of TFII-I during BMP-2-driven osteoblast differentiation in the C2C12 cell line. Our results show that TFII-I plays an inhibitory role in regulating genes that are essential in osteogenesis and intersects with the bone-specific transcription factor Runx2 and the retinoblastoma protein, pRb. Identification of pathways regulated by TFII-I family transcription factors may begin to shed light on the molecular determinants of WBS."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c109.063115"xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/author | "Roy A.L."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/author | "Hinds P.W."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/author | "Tussie-Luna M.I."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/author | "Lazebnik M.B."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/pages | "36234-36239"xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/title | "Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes."xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19880526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19880526 |
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| http://purl.uniprot.org/uniprot/#_E0CZ12-mappedCitation-19880526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880526 |
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