| http://purl.uniprot.org/citations/19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19880579 | http://www.w3.org/2000/01/rdf-schema#comment | "Sustained extracellular signal-regulated kinase (ERK)-signaling plays a critical role in T-cell-mediated IL-2 production. Although many downstream targets are known for ERK, details remain unknown about which molecules play functional roles in IL-2 production. Here, we addressed this question using proteomic analysis of nuclear proteins from TCR-activated T cells and identified hnRNP-K as one of the ERK targets essential for IL-2 production. hnRNP-K was previously shown by others to be a direct substrate of ERK and form complexes with multiple signaling proteins as well as DNA and RNA. Our data showed a clear ERK-dependent increase in one form of hnRNP-K after TCR stimulation. Small interfering RNA-mediated gene knockdown of hnRNP-K expression abrogated IL-2 production by T cells. Moreover, reduction of hnRNP-K expression caused a notable increase in proteolysis of Vav1, a binding target of hnRNP-K. Since Vav1 is an essential molecule for T-cell activation, the data suggest that ERK signaling is required for T-cell activation partly by inhibiting activation-induced proteolysis of Vav1."xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxp106"xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/author | "Koike T."xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/author | "Chang J.W."xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/author | "Iwashima M."xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/pages | "1351-1361"xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/title | "hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation."xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19880579 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19880579 |
| http://purl.uniprot.org/citations/19880579 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MR07-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A286YDH1-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A286YDM3-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A286YE41-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A286YEC4-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A338P736-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A338P781-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_B4DFF1-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A286YCM2-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SZ57-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |
| http://purl.uniprot.org/uniprot/#_B2R8B5-mappedCitation-19880579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19880579 |