| http://purl.uniprot.org/citations/19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19881537 | http://www.w3.org/2000/01/rdf-schema#comment | "The germinal center (GC) reaction has a pivotal function in human B-cell lymphomagenesis. Genetic aberrations occurring during somatic hypermutation and class switch recombination deregulate key factors controlling B-cell physiology and proliferation. Several human lymphoma entities are characterized by a constitutive GC phenotype and ongoing somatic hypermutation, but the molecular basis for this phenomenon is only partly understood. We have investigated the reasons for a constitutive GC-like program in Burkitt's lymphoma cells. Here, overexpression of c-Myc leads to a centroblast phenotype, promotes high constitutive expression of the key GC factors Bcl-6, E2A and activation-induced cytidine deaminase and contributes to proliferation and somatic hypermutation. Our findings elucidate how the activity of a pivotal transcription factor may freeze B-cell lymphoma cells in a constitutive GC-like state that is even maintained at an extrafollicular location."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.377"xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Eder M."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Scheller H."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Jungnickel B."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Kutzera A."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Tobollik S."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Pfeil I."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/author | "Unterlehberg J."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/pages | "888-897"xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/title | "c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma."xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19881537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19881537 |
| http://purl.uniprot.org/citations/19881537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19881537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |
| http://purl.uniprot.org/uniprot/#_B3CJB8-mappedCitation-19881537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881537 |