| http://purl.uniprot.org/citations/19881551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19881551 | http://www.w3.org/2000/01/rdf-schema#comment | "In cancer cells, glucose is often converted into lactic acid, which is known as the 'Warburg effect'. The reason that cancer cells have a higher rate of aerobic glycolysis, but not oxidative phosphorylation, remains largely unclear. Herein, we proposed an epigenetic mechanism of the Warburg effect. Fructose-1,6-bisphosphatase-1 (FBP1), which functions to antagonize glycolysis was downregulated through NF-kappaB pathway in Ras-transformed NIH3T3 cells. Restoration of FBP1 expression suppressed anchorage-independent growth, indicating the relevance of FBP1 downregulation in carcinogenesis. Indeed, FBP1 was downregulated in gastric carcinomas (P<0.01, n=22) and gastric cancer cell lines (57%, 4/7). Restoration of FBP1 expression reduced growth and glycolysis in gastric cancer cells. Moreover, FBP1 downregulation was reversed by pharmacological demethylation. Its promoter was hypermethylated in gastric cancer cell lines (57%, 4/7) and gastric carcinomas (33%, 33/101). Inhibition of NF-kappaB restored FBP1 expression, partially through demethylation of FBP1 promoter. Notably, Cox regression analysis revealed FBP1 promoter methylation as an independent prognosis predicator for gastric cancer (hazard ratio: 3.60, P=0.010). In summary, we found that NF-kappaB functions downstream of Ras to promote epigenetic downregulation of FBP1. Promoter methylation of FBP1 can be used as a new biomarker for prognosis prediction of gastric cancer. Such an important epigenetic link between glycolysis and carcinogenesis partly explains the Warburg effect."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.332"xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Sung J.J."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Jin H.C."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Chan F.K."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Shin V.Y."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Cheng A.S."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/author | "Lam E.K."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/pages | "442-450"xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/title | "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19881551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19881551 |
| http://purl.uniprot.org/citations/19881551 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19881551 |
| http://purl.uniprot.org/uniprot/P09467#attribution-2B91C0EC6BD4438253EB996E9AAEF511 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19881551 |
| http://purl.uniprot.org/uniprot/P19838#attribution-81486BDFFA9794F6F7A245FD26D67EB6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19881551 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ1-mappedCitation-19881551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881551 |
| http://purl.uniprot.org/uniprot/#_Q0VDV7-mappedCitation-19881551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881551 |
| http://purl.uniprot.org/uniprot/#_A0A5P8I3H7-mappedCitation-19881551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19881551 |