| http://purl.uniprot.org/citations/19883582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19883582 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic circadian clocks include interconnected positive and negative feedback loops. The clock-cycle dimer (CLK-CYC) and its homolog, CLK-BMAL1, are key transcriptional activators of central components of the Drosophila and mammalian circadian networks, respectively. In Drosophila, negative loops include period-timeless and vrille; positive loops include par domain protein 1. Clockwork orange (CWO) is a recently discovered negative transcription factor with unusual effects on period, timeless, vrille, and par domain protein 1. To understand the actions of this protein, we introduced a new system of ordinary differential equations to model regulatory networks. The model is faithful in the sense that it replicates biological observations. CWO loop actions elevate CLK-CYC; the transcription of direct targets responds by integrating opposing signals from CWO and CLK-CYC. Loop regulation and integration of opposite transcriptional signals appear to be central mechanisms as they also explain paradoxical effects of period gain-of-function and null mutations."xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bpj.2009.08.018"xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/author | "Fathallah-Shaykh H.M."xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/author | "Kadener S."xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/author | "Bona J.L."xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/pages | "2399-2408"xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/title | "Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration."xsd:string |
| http://purl.uniprot.org/citations/19883582 | http://purl.uniprot.org/core/volume | "97"xsd:string |
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