| http://purl.uniprot.org/citations/19883641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19883641 | http://www.w3.org/2000/01/rdf-schema#comment | "First described as a cell cycle activator, RGC-32 is both an activator and a substrate for CDC2. Deregulation of RGC-32 expression has been detected in a wide variety of human cancers. We have now shown that RGC-32 is expressed in precancerous states, and its expression is significantly higher in adenomas than in normal colon tissue. The expression of RGC-32 was higher in advanced stages of colon cancer than in precancerous states or the initial stages of colon cancer. In order to identify the genes that are regulated by RGC-32, we used gene array analysis to investigate the effect of RGC-32 knockdown on gene expression in the SW480 colon cancer cell line. Of the 230 genes that were differentially regulated after RGC-32 knockdown, a group of genes involved in chromatin assembly were the most significantly regulated in these cells: RGC-32 knockdown induced an increase in acetylation of histones H2B lysine 5 (H2BK5), H2BK15, H3K9, H3K18, and H4K8. RGC-32 silencing was also associated with decreased expression of SIRT1 and decreased trimethylation of histone H3K27 (H3K27me3). In addition, RGC-32 knockdown caused a significantly higher percentage of SW480 cells to enter S phase and subsequently G2/M. These data suggest that RGC-32 may contribute to the development of colon cancer by regulating chromatin assembly."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexmp.2009.10.010"xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Nguyen V."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Fosbrink M."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Rus H."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Rus V."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Shamsuddin A."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Azimzadeh P."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Tegla C.A."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Cudrici C.D."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Mircea P.A."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/author | "Vlaicu S.I."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/name | "Exp Mol Pathol"xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/pages | "67-76"xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/title | "Epigenetic modifications induced by RGC-32 in colon cancer."xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/19883641 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19883641 |
| http://purl.uniprot.org/citations/19883641 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19883641 |
| http://purl.uniprot.org/uniprot/#_P57053-mappedCitation-19883641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19883641 |
| http://purl.uniprot.org/uniprot/#_P58876-mappedCitation-19883641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19883641 |
| http://purl.uniprot.org/uniprot/#_P62807-mappedCitation-19883641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19883641 |
| http://purl.uniprot.org/uniprot/#_P33778-mappedCitation-19883641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19883641 |