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http://purl.uniprot.org/citations/19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19884273http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To examine the role of HLA-DRB1 and HLA-DQB1 alleles in the susceptibility to systemic sclerosis (SSc) and its clinical expression in a Spanish population.

Methods

One hundred Spanish Caucasian patients with SSc and 130 controls were studied. Molecular HLA-DRB1 and HLA-DQB1 typing was performed by polymerase chain reaction (PCR) sequence-based typing and PCR sequence-specific oligonucleotide.

Results

HLA-DRB1*11 was associated with genetic susceptibility to SSc, whereas HLA-DRB1*07 (HLA-DRB1*0701) showed a protective effect. A significant increase in the frequency of the DRB1*1104 allele was observed in patients with anti-topoisomerase I autoantibodies (anti-Topo I) while HLA-DRB1*01 and HLA-DQB1*05 alleles were significantly increased in patients with anti-centromere antibodies (ACA). The HLA-DRB1*11 allele was more frequent in patients with pulmonary fibrosis; however, no significant association with any HLA-DRB1 or DQB1 alleles was identified in patients with pulmonary arterial hypertension.

Conclusion

HLA alleles play a role in genetic susceptibility to SSc in Spanish patients. Some alleles are more prevalent in patients with pulmonary fibrosis and in patients with certain SSc-specific autoantibodies (anti-Topo I and ACA)."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.org/dc/terms/identifier"doi:10.3899/jrheum.090377"xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Moreno E."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Palou E."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Armadans L."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Vilardell M."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Marsal S."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Fonollosa V."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Tolosa C."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Simeon C.P."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Selva A."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/author"Solans R."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/pages"2733-2736"xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/title"Association of HLA class II genes with systemic sclerosis in Spanish patients."xsd:string
http://purl.uniprot.org/citations/19884273http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/19884273http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19884273
http://purl.uniprot.org/citations/19884273http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19884273
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19884273
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19884273
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19884273
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19884273
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-19884273http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19884273
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